What is a common side effect of using acepromazine in horses?

• A. Hyperactivity
• B. Hypotension and increased sensitivity to other sedatives
• C. Increased heart rate
• D. Reduced appetite

Answer: (B)

When using acepromazine in horses, a common and notable side effect is hypotension and increased sensitivity to other sedatives. Acepromazine is a phenothiazine tranquilizer that possesses sedative properties, and one of the effects it can have is lowering blood pressure, or hypotension. This can happen due to the drug's ability to block certain receptors in the body, leading to vasodilation. This side effect is particularly important when considering the use of other sedatives or anesthetics, as the concomitant use can exacerbate hypotensive effects, making careful dosage and monitoring essential.

Additionally, the increased sensitivity to other sedatives means that horses may respond differently to additional doses of sedatives or anesthetics after receiving acepromazine, necessitating adjustments in dosing and careful observation to ensure the animal remains safe and stable. Understanding these effects is critical in managing anesthesia in field settings to minimize risks associated with sedation, particularly with the potential for compounded effects.