What is a primary concern when using acepromazine in anesthesia?

• A. Potential for increased heart rate
• B. Risk of respiratory depression
• C. Hypotension and increased sensitivity to other sedatives
• D. Delayed recovery time

Answer: (C)

The primary concern when using acepromazine in anesthesia is its potential to cause hypotension and increase sensitivity to other sedatives. Acepromazine acts as a tranquilizer and is known for its alpha-adrenergic blocking effects, which can lead to vasodilation and, consequently, a decrease in blood pressure. This hypotension is significant because it can exacerbate the effects of other sedative medications used in combination, leading to unpredictable outcomes during anesthesia.

Additionally, understanding the pharmacodynamics of acepromazine can help clinicians manage intravenous fluid therapy or monitor blood pressure more closely, especially in patients with existing cardiovascular issues. Recognizing this concern is crucial for ensuring the safety and well-being of the animal during anesthesia, highlighting the need for careful monitoring and dosage adjustments when using acepromazine in conjunction with other drugs.