What is the main reason for using a COX selective NSAID like Meloxicam in cattle?

• A. It is effective for high fevers
• B. It causes less gastrointestinal upset
• C. It can be given intramuscularly
• D. It enhances appetite

Answer: (B)

The main reason for using a COX selective NSAID like Meloxicam in cattle is that it causes less gastrointestinal upset compared to non-selective NSAIDs. COX, or cyclooxygenase, has two main isoforms: COX-1 and COX-2. Non-selective NSAIDs inhibit both isoforms, which can lead to gastrointestinal irritation, ulceration, and other adverse effects because COX-1 is involved in maintaining the protective lining of the gastrointestinal tract.

On the other hand, COX selective NSAIDs such as Meloxicam primarily inhibit COX-2, which is more involved in the inflammatory process. This selectivity helps to minimize the negative impacts on the gastrointestinal system, making these medications safer for long-term use in treating pain and inflammation in cattle. Thus, the use of Meloxicam can provide effective pain relief while reducing the risk of gastrointestinal complications, which is essential for maintaining the health and well-being of the animals being treated.