What off-label NSAID option is COX selective and suitable for pain control greater than three days?

• A. Phenylbutazone
• B. Meloxicam
• C. Ketoprofen
• D. Aspirin

Answer: (B)

Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that is selective for cyclooxygenase-2 (COX-2), which makes it particularly effective in managing pain and inflammation while minimizing gastrointestinal side effects commonly associated with non-selective NSAIDs. Its longer duration of action allows it to provide effective pain control beyond three days, making it suitable for chronic pain management in various food animals.

Meloxicam's COX-2 selectivity means it targets the enzyme involved in the inflammatory process more specifically, offering anti-inflammatory effects while sparing COX-1, which plays a role in protecting the gastrointestinal mucosa. This characteristic helps practitioners minimize the risks of complications such as ulcers or gastrointestinal bleeding, which may arise with other NSAIDs, especially when used over extended periods.

While the other options listed are also NSAIDs, they do not share the same profile regarding COX selectivity or duration of effectiveness. Phenylbutazone, for example, is a non-selective NSAID effective for pain relief, but it may have a higher risk of gastrointestinal side effects. Ketoprofen, while also utilized for analgesia, does not typically have the same protracted effect as meloxicam. Aspirin, another